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KMID : 0360419690050020041
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Korean Journal of Pharmacology
1969 Volume.5 No. 2 p.41 ~ p.45
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Studies on the Adrenotropic Receptors of the Isolated Urinary Bladder from Sebastes Inermis
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Abstract
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The authors studied the adrenotropic receptors of isolated urinary bladder from Sebastes inermis, using adrenergic activators such as epinephrine, nor-epinephrine, isoproterenol and phenylephrine and adrenergic blocking agents such as phenoxybenzamine, pronethalol and propranolol. The studies have revealed the following results.
1) The spontaneous motility of isolated bladder from Sebastes inermis was inhibited by epinephrine nor-epinephrine, isoproterenol and phenylephrine.
2) The inhibitory effect of phenylephrine on the Sebastes inermis bladder was blocked by phenoxybenzamine.
3) The inhibitory effect of isoproterenol was blocked by Pronethalol and Propranolol.
4) The effect of epinephrine and nor-epinephrine on the Sebastes inermis bladder was usually not blocked by either kind of blocking agent alone, but was blocked by a combination of a α and β blockades.
5) It is, therefore, concluded that the Sebastes inermis bladder has alpha and beta receptors, and that both receptors subserve relaxation or inhibition.
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